Thyroid Health

The epigenetic environment and our reality

• He epigenetic environment impacts our biological reality.
• Our metabolism responds to neuronal signals from the environment.
• The
• Neurons detect stimuli and send signals to the hypothalamus.
• He
• hypothalamus
• regulates vital functions such as temperature, oxygen, pH and hunger.
• The hypothalamus secretes
• hypothalamic hormones
• s that affect the
• pituitary gland.

THE THYROID PATHWAY

1. Secretion of hormones:

• The hypothalamus secretes HRT to stimulate the pituitary gland to release TSH.
• The hormone
• TSH
• (thyroid stimulating hormone) will stimulate the
• thyroid gland.
• Reference ranges may vary slightly by laboratory and population, normal TSH levels in adults are between 0.4 and 4.0 mU/L. Optimal levels are 1.8 to 3.0 mU/L

2. Synthesis of thyroid hormones:

• The thyroid uses thyroperoxidase (TPO) enzyme to iodize the thyroglobulin (TGB) and form thyroid hormones triiodothyronine (T3) and thyroxine (T4).

  3. Requirements for synthesis:

  • For the synthesis of thyroid hormones you need:
  • Iodine:
  • It is an essential mineral that is obtained from the diet.
  • Iron:
  • It is found in hemoglobin and myoglobin, and is necessary for the synthesis of
  • TPO.
  • Tyrosine
  • : It is an amino acid that is obtained from dietary proteins.
  • TSHR gene:
  • what he finds in the
  • chromosome 19
  • . This gene codes for the receptor
  • TSH,
  • which is necessary for the thyroid response to
  • TSH.

  4. Action of thyroid hormones:

  • The T3 It is the primarily active thyroid hormone. Binds to receptors thyroid hormone (TR) located in the nucleus of the cells.
  • The Union of
  • T3 to TR
  • It induces a change in its conformation, which allows it to act as a transcription factor.
  • Transcription of
  • mRNA
  • : The complex
  • T3-TR
  • binds to specific DNA sequences in the promoters of target genes, initiating transcription of
  • messenger RNA (mRNA)
  • .
  • The mRNA
  • It is translated by ribosomes into specific proteins, which exert various effects on the cell.

  5. Conversion from T4 to T3:

  • The T4 becomes active T3 mainly in the liver, but also in other tissues such as kidneys and brain .
  • For this, it will require the
  • enzyme 5'-deiodinase enzyme
  • which depends on
  • selenium
  • and zinc
  • .
  • The enzyme will remove an atom from the
  • T4
  • to turn it into
  • T3
  • active.

  6. Negative feedback:

  • When there is too much T4 and T3 in the blood, a negative feedback . The hypothalamus stops the secretion of HRT and the pituitary gland stops secreting TSH , which reduces thyroid stimulation until it regulates normal values. This helps keep thyroid hormone levels in a normal range, acting like a thermostat.
    

T3 and the formation of ATP or Energy in cells

The thyroid hormone T3 is involved in the formation of energy in the cell in various ways:

1. Increasing mitochondrial activity:

• The T3 increases ATP production, the main energy molecule of the cell, by stimulating the activity of the mitochondria.
• Mitochondria are the organelles responsible for cellular respiration, the process by which cells convert glucose into ATP.
• The T3 increases the synthesis of mitochondrial enzymes and transport of substrates to mitochondria, which optimizes energy production.

2. Increasing thermogenesis:

• The T3 promotes the thermogenesis, which is the production of heat by the body.
• This heat is generated mainly in the muscle and fatty tissues.
• The T3 increases the activity of the Na /K ATPase, a ion pump that consumes ATP and generates heat as a byproduct.
• Thermogenesis helps maintain body temperature and burn calories, which contributes to weight control.

3. Stimulating gluconeogenesis:

• The T3 favors the gluconeogenesis, which is the synthesis process of glucose from non-glucidic substrates such as lactate, pyruvate and amino acids.
• The glucose is the main source of energy for many tissues, including the brain and red blood cells.
• The stimulation of gluconeogenesis by T3 ensures adequate glucose supply even in conditions fasting or low carbohydrate consumption.

4. Improving insulin sensitivity:

• The T3 increases insulin sensitivity, the hormone that regulates glucose metabolism.
• Insulin allows glucose to enter cells to be used for energy.
• Greater insulin sensitivity means cells can take up and use glucose more efficiently, lowering blood glucose levels and improving diabetes control.

5. Influencing gene expression:

• The T3 regulates gene expression that code for proteins involved in energy metabolism.
• The T3 can activate or deactivate the expression of these genes according to the energy needs of the body.
• For example, the T3 can increase the expression of genes that code for glycolytic enzymes, what favors the glucose breakdown and energy production.



It is important to note that T3 is not the only hormone that regulates energy metabolism. Other hormones, such as adrenaline, cortisol, and leptin, also play important roles in this process.

Early detections

To know if something is not working well with your thyroid, especially when it is low or hypothyroidism, there are certain clues that can serve as a guide, such as:

Weight gain, even if you eat the same thing as always, feeling of low energy, apathy and leaving things unfinished, hair loss, mood swings, especially depression, mental work becomes heavy, things are forgotten, skin and tissues age. Swollen legs, hypertension, diabetes and overweight begin to appear.

When any of this is happening, it is time to analyze whether the problem is a malfunctioning thyroid.

The precedents that can help to know if the thyroid is affected are:

• Eating and having eaten fast food or junk food.
• Abuse of soft drink consumption.
• Consumption of bread and gluten.
• Use preservatives in food; bottled sauces, mayonnaise, ketchup, bouillon cubes, canned or tetra brick soups.
• Eating too much oily fish, which may contain mercury, or having metal fillings in your teeth.
• Abuse of vegetables and fruits that may contain goitrogens.
• Use toothpaste with fluoride, or let your dentist put fluoride on you directly.
• Drink tap or bottled water.
• Start to have some allergies.
• Feeling intoxicated, it is noticeable because there is a bad odor in the body, halitosis, etc.
• Constipation or diarrhea problems.
• Constant diets and fasts to lose weight.
• Excess exercise from which one does not recover quickly.
  

Any of these habits can be a precursor to an affected metabolism and make it very difficult for the doctor to detect it with an analysis.

Associated conditions

• Poor nutrition, even if the food is sufficient.
• Lack of minerals: Selenium, Zinc and Iron.
• Vitamin deficiency, especially: C, E, D and B.
• Lack of outdoor exercise.
• Excess responsibility that leaves no room for rest and relaxation.
• Insomnia or sleeping poorly.
• Humor changes.
• Little or no menstruation.
• Difficulty in pregnancy.
• Poor sperm mobility.
• Little amount of sperm.
• Recurrent infections.
• Allergies
• Inflammatory processes, especially in the intestine.
• Autoimmune diseases.

Solutions

1. Major change in diet.
2. Don't eat gluten
3. Avoid foods with goitrogens for a long time.
4. Change your toothpaste to one that does not contain fluoride.
5. Buy a water filter that removes fluoride, chlorine and contaminating residues.
6. Do not eat blue fish, preferably white.
7. Change metal fillings for white ones (in this case, ask why a special procedure is necessary, to avoid swallowing metal residue from the fillings that are being removed and which can worsen mercury contamination)
8. Do not eat fast food and do not drink soft drinks.
9. Eliminate white sugar and desserts from your diet.
10. Regulate your exercise if you do too much, or take up walks outside if you don't.

1. Start therapy with gENiO SAPIENS to eliminate toxins and control thyroid function (you can use zap echoes with hypothyroidism or hyperthyroidism)
2. Do a complete laboratory analysis of the thyroid and immune system.
   

Accessories

• Consume before anything high quality fats, not Trans fats, nor oxidized fats.
• Use virgin Olive Oil (first cold pressed) for salads.
• Cleanse the liver with NAC
• Cleanse the intestine with DuoLife Aloe
• To drink My Blood by DuoLife 3 months in a row.
• Depending on the analysis, complement with DuoLife Day and Night.
• In cases of autoimmune problem take IMMUNODIN
• Complement with SEDANIT or ProRelaxin, in case of stress, insomnia or depression.

  Dr. Eduardo González C.

  ® 05/07/20242008064953469